top of page
STRESS AND MODELS OF DEPRESSION
In the McGirr lab, models of stress-based depression are studied to explore the pathophysiological mechanisms of mood disorders.
![](https://static.wixstatic.com/media/8c9811_e480e93d0a2c499aa2bf41935e68828cf000.jpg/v1/fill/w_619,h_310,al_c,lg_1,q_80,enc_avif,quality_auto/8c9811_e480e93d0a2c499aa2bf41935e68828cf000.jpg)
![](https://static.wixstatic.com/media/11062b_03c50f8fe4a34cc297a984e483a282eff000.jpg/v1/fill/w_980,h_551,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/11062b_03c50f8fe4a34cc297a984e483a282eff000.jpg)
We study cellular and network level changes after stress using a range of techniques:
FLUORESCENT INDICATORS OF NEURONAL ACTIVITY
![GCaMP6s-3AMBUK-400.png](https://static.wixstatic.com/media/8c9811_7db189ae849d48d792475297fba9d227~mv2.png/v1/fill/w_301,h_245,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/GCaMP6s-3AMBUK-400.png)
OPTOGENETIC STIMULATION
![MIT-Label-Neurons_0.jpg](https://static.wixstatic.com/media/8c9811_86bdbbd68f5541a88309e079093a1b0c~mv2.jpg/v1/fill/w_301,h_245,al_c,q_80,usm_0.66_1.00_0.01,enc_avif,quality_auto/MIT-Label-Neurons_0.jpg)
BEHAVIORAL AND PHARMACOLOGICAL STUDIES
![brainpillg626957962_1402158-860x484.jpg](https://static.wixstatic.com/media/8c9811_fa17f70494744af590ebb7d9be412f7d~mv2.jpg/v1/fill/w_301,h_245,al_c,q_80,usm_0.66_1.00_0.01,enc_avif,quality_auto/brainpillg626957962_1402158-860x484.jpg)
bottom of page